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[DOI] [PubMed] [Google Scholar] 19.Lee YC, Lee KS, Park SJ, et al

CDR = Clinical Dementia Rating

Taken together, all these findings support our hypothesis that the combined administration of high doses of classical antineoplastic agents intended to sensitize tumors to immunotherapy or radiotherapy may ultimately trigger multi-drug resistance

Notably, KRAS mutations reduce lipase levels, thereby increasing lipid storage and suppressing FA metabolism, which allows stored lipids to further support invasion and metastasis [31]